Job Advertisement HKI-09/2017

The Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute – (HKI, www.leibniz-hki.de) investigates the pathobiology of human-pathogenic fungi and identifies targets for the development of novel natural product-based antibiotics. TheDepartment of Infection Biology invites talented and highly gifted candidates to apply for a

Doctoral Researcher (Infection Biology)

for two years initially.

Successful candidates will investigate the field Complement Genetics in Renal and Retinal Diseases. Main topics of the project are

  • Identification of Genetic Mutations of Complement Genes in Renal and Retinal Disease C3 Glomerulopathy, HUS and AMD
  • Next Generation Sequencing for Genetic Diagnostics
  • Functional characterization of CFHR1, CFHR3 and CFHR5 proteins

For further details please see literature below.

Requirements:

  • Master degree in biology, genetics or life sciences.
  • Experience, knowledge and good experimental skills in molecular biology, genetic, biochemistry are an advantage.

Literature:
  • Chen Q, Manzke M, Hartmann A, Büttner M, Amann K, Pauly D,  Wiesener M, Skerka C, Zipfel PF (2016) CFHR5-Hybrid Proteins Anchor Properdin and Activate Complement at Self-Surfaces. J Am Soc Nephrol, in press
  • Chen Q, Wiesener M, Eberhardt HU, Hartmann A, Uzonyi B, Kirschfink M, Amann K, Büttner M, Goodship T, Hugo C, Skerka C, Zipfel PF (2014) Complement factor H related hybrid protein deregulates complement in dense deposit disease. J Clin Invest 124, 145-155.
  • Zipfel PF, Skerka C, Chen Q, Wiech T, Goodship T, Johnson S, Fremeaux-Bacchi V, Nester C, de Córdoba SR, Noris M, Pickering M, Smith R (2015) The role of Complement in C3 Glomerulopathy. Mol Immunol 67(1):21-30
  • Zipfel PF, Skerka C (2009) Complement regulators and inhibitory proteins. Nat Rev Immunol 9, 729-740.

For further information

Please contact Peter Zipfel | +49 3641 532 1300 | peter.zipfel@leibniz-hki.de.

Applications

Salary is paid according to German TV-L (salary agreement for public service employees). The HKI is committed to increase the percentage of female scientists and therefore especially encourages them to apply.

Complete applications in English or German should include a letter of interest, curriculum vitae, a complete list of publications, brief statement of research experiences, a list of three potential references, full academic record (copies of degree certificates), and should be submitted by 21.04.2017 via the online application system.